Development of amphotericin b Based organogels against mucocutaneous fungal infections

Amphotericin B is a broad spectrum antifungal agent used to treat fungal infections. Organogel is a semisolid preparation in which the apolar phase gets immobilized within spaces of the threedimensional structure. The current study aimed at the formulation and comparative evaluation of sorbitan monostearate organogels and pluronic lecithin organogels (PLO). Different compositions of span 60 based organogels were prepared by varying the concentrations of the span 60 and PLO gels were prepared by varying the concentration of Pluronic F 127. The developed organogels were subjected to various characteristics such as pH, viscosity, spreadability, extrudability, and drug release studies. The optimized formulations were evaluated against Candida albicans and carried out ex vivo release study. The optimized formulation was selected from span 60 based organogels, and pluronic lecithin organogels were S1 and P1, respectively. The optimized formulation (S1) showed effective inhibition against Candida albicans. The skin irritation test was carried out on albino mice for optimized formulations and results showed that no irritation to the skin. Based on the results, organogels prepared by sorbitan monostearate showed better antifungal activity, and also all the formulations were found to be stable and safe throughout the study period

Development of EOG Based Human Machine Interface Control System for Motorized Wheelchair

Abstract Rehabilitation devices are increasingly being used to improve the quality of the life of differentially abled people. Human Machine Interface (HMI) have been studied extensively to control electromechanical rehabilitation aids using biosignals such as EEG, EOG and EMG etc. among the various biosignals, EOG signals have been studied in depth due to the occurrence of a definite signal pattern. Persons suffering from extremely limited peripheral mobility like paraplegia or quadriplegia usually have the ability to coordinate eye movements. The current project focuses on the development of a prototype motor wheelchair controlled by EOG signals. EOG signals were used to generate control signals for the movement of the wheelchair. As a part of this work an EOG signal acquisition system was developed. The acquired EOG signal was then processed to generate various control signals depending upon the amplitude and duration of signal components. These control signals were then used to control the movements of the prototype motorized wheelchair model

A low-cost system for remote access and control of automation equipment

The shift towards remote access and control of equipment has become more prominent, especially due to COVID-19 lockdowns. Access to physical/real equipment for practical learning remains important for engineering studies. Thus, this paper presents an approach for remotely accessing and controlling automation equipment for engineering practical activities. Specifically, it addresses the issue of accessing and controlling machines for programmable logic controller (PLC) programming tasks. The combination of a scheduler, remote desktop access, graphical user interface, and a micro-controller allows students to work remotely on practical equipment. The lab computer can be accessed via a remote computer to select one of multiple equipment for practical activities. A prototype system was constructed as proof of concept. The prototype system functions as required

Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities

Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables is critical for a continued progress in oral drug development. In this review, different methodologies (invasive versus non-invasive) to explore the impact of physiological variables on formulation behavior in the human GI tract are presented, revealing their strengths and limitations. The techniques mentioned allow for an improved understanding of the role of following GI variables: gastric emptying (magnetic resonance imaging (MRI), scintigraphy, acetaminophen absorption technique, ultrasonography, breath test, intraluminal sampling and telemetry), motility (MRI, small intestinal/colonic manometry and telemetry), GI volume changes (MRI and ultrasonography), temperature (telemetry) and intraluminal pH (intraluminal sampling and telemetry)

The Transformative Role of Nursing Leaders in Mergers and Acquisitions within the Ostrobothnia Welfare area

Transformational leadership is widely acknowledged in healthcare reforms hence it focuses on transformation, and it establishes a positive change in the organization. In nursing care, transformative leadership is inevitable, and the leader's function holistically in motivating the team members to strive towards the goal of the organization. As concerned with the centralization of the Ostrobothnia welfare area, numerous changes have been made and this is an explorative study, using semi structured interviews to determine the transformative role of nursing leaders during the fusion process. The aim of the study is to explore the nursing leader’s functional area in the Ostrobothnia healthcare reform process and the research questions are. 1) Which transformative role do nurse leaders/managers prefer when leading in merging processes? 2) What are the challenges and strengths for each role chosen during the change process? The background of the study is based on healthcare reforms, leadership during transformation, elements of transformational leadership and exemplary leadership practices in confronting leadership challenges. The study succeeded in answering both research questions as the result identified the influential, intellectual, motivational, and considerate role of the nursing leaders in leading the change process and the strengths and challenges of each role they prefer despite the fact of the fusion process is still ongoing

An Investigation of the Resonant and Non-Resonant Angular Time Delay of e-C₆₀ Elastic Scattering

Time delay in electron scattering depends on both the scattering angle θ and scattered electron energy E. A study on the angular time delay of e-C60 elastic scattering was carried out in the present work. We employed the annular square well (ASW) potential to simulate the C60 environment. The contribution from different partial waves to the total angular time delay profile was examined in detail. The investigation was performed for both resonant and non-resonant energies, and salient characteristics in the time delay profile for each case were studied

Impact of Charge Migration and the Angle-Resolved Photoionization Time Delays of the Free and Confined Atom X@C60_{60}

The present study is devoted to isolate and study the effect of charge migration on the photoionization from the X@C$_{60}$. The noble gas atoms, Ar, Kr, and Xe, are confined in the C$_{60}$ to investigate the impact of charge migration from the entrapped atom to the C$_{60}$ side. The present work concludes that the confinement oscillations in the photoionization features are amplified due to the charge migration. Further, the angle-resolved, spin average time delay is also investigated in the light of confinement. Features in the time delay due to the charge migration are more amplified relative to those in the cross-section or angular distribution